Despite advances in technology and increased spending, the number of new drugs approved per billion dollars spent on research and development has halved approximately every nine years since the 1950s. This trend was first identified in 2012 and humorously called Eroom’s Law (Moore backward).
You probably want to read what is working in big pharma like, stories from employees might help you divise the scaling culture.
When it's hard to make progress... Nobody expected quick or cheap progress
Or even success bureacracy at it's finest
Do you happen to know what this looks like if it's inflation-adjusted? Probably still pretty stark, but much closer to where it was.